Students will learn about advanced topics in Structural Biology through lectures and dissection of the primary literature. Methods covered in detail will include X-ray crystallography, NMR, and cryo-EM, including single particle analysis and tomography. Applications and integrative approaches will be highlighted. The course will include practical sessions aimed at providing hands-on experience with protein structure solution and sample preparation. Students will further develop their independent thinking, knowledge of the techniques utilized in these areas, and ability to critically assess the literature.
Target group: Students working with structural biology methods as part of their PhD; scientists wishing to understand how protein (complex) structures are obtained and interpreted.
Prerequisites: While this course can be taken as standalone, students are encouraged to attend the “Protein Function, Structure and Dynamics” Course in Spring 1, which will cover the fundamentals of protein biochemistry.
Evaluation: Grading scheme: Pass/fail
Final exam must be positive
Teaching format: None
ECTS: 3 Year: 2025
Track segment(s):
Elective
Teacher(s):
Jack Bravo
Florian Praetorius
Paul Schanda
Carrie Bernecky
Florian Schur
Leonid Sazanov
Teaching assistant(s):
- Trainer/in: Carrie Bernecky
- Trainer/in: Jack Bravo
- Trainer/in: Florian Praetorius
- Trainer/in: Leonid Sazanov
- Trainer/in: Paul Schanda
- Trainer/in: Florian Schur