Nuclear Magnetic Resonance spectroscopy is arguably the most widely used analytical spectroscopic technique, covering applications from organic chemistry to structural biology, analysis of material, study of batteries at work, and even in situ analysis of artwork or search for oil in the soil. Many chemists use it on a routine basis, and many in a somewhat black-box manner.
This course will go beyond the "black box" and will teach the foundations to truly understand what is going on in an NMR experiment, from instrumentation to pulse sequence to data processing and interpretation. (A dedicated "spectra interpretation course" is separately offered in Spring 2.)
Contents:
* Quantum mechanical basis of NMR: energy levels, eigenstates, matrix representation, product operators
* Understanding NMR pulse sequences (one- to multi-dimensional) using product operators
* NMR instrumentation (including hands-on session)
* Fourier transformation and NMR data processing
* Techniques and their information content: diffusion, correlation spectroscopy, basis of structure determination of biomolecules
Target group: Structural biologists and chemists who want to work with NMR, and/or who want to understand this spectroscopic method.
Prerequisites: Participants should have a basic understanding what a molecule is, but otherwise no prerequisites.
Evaluation: Final exam
Teaching format: Lectures and recitations which will comprise: solving of problem sets, working at the spectrometer.
ECTS: 3 Year: 2024
Track segment(s):
Elective
Teacher(s):
Petra Rovó
Paul Schanda
Teaching assistant(s):
Jakob Schneider
- Trainer/in: Petra ROVO
- Trainer/in: Paul Schanda
- Teaching Assistant: Jakob Schneider